ugd [2019-02-27 17:31:05]

UDP-glucose dehydrogenase

Locus: BSU36230

Isoelectric point: 5.03

Molecular weight: 47.62 kDa

Protein length: 440 aa

Gene length: 1323 bp

Function: unknown

Product: UDP-glucose dehydrogenase

Essential: no

E.C.: 1.1.1.22

Synonyms: ywqF

Genomic Context

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Categories containing this gene/protein

• Groups of genes → Phosphoproteins → Phosphorylation on a Tyr residue

Gene

Coordinates: 3,729,488 3,730,810

The protein

Catalyzed reaction/ biological activity

• UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH (according to Swiss-Prot)

Protein family

• UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

Paralogous protein(s)

• YtcA, TuaD

Modification

• phosphorylation on Tyr-70 by PtkA PubMed, dephosphorylated by PtpZ PubMed

Effectors of protein activity

• phosphorylation by PtkA stimulates activity of Ugd PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: tkmA-ptkA-ptpZ-ugd
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • Spo0A: activation, PubMed, in Spo0A regulon
  • DegU: activation, DegU-P, PubMed, in DegU regulon
  • AbrB: repression, PubMed, in AbrB regulon

Biological materials

Mutant

• BKE36230 (ugd::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTTTCCCTCCAACAGT, downstream forward: _UP4_TAGATGAAAAAGAAAGGCTG

References

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